The TRANSIENCE project will create an open, integrated, modular framework to simulate pathways toward achieving the transition of European industries to climate neutrality while fully integrating material efficiency and circular economy measures in energy and climate models. To do this, it will bring together the consortium’s high-level expertise behind, and backbones of, well-established models in actively informing climate, energy, and industrial policies in Europe, addressing concerns related to broader sustainability, including environmental synergies or trade-offs, changes in industrial output, employment, competitiveness, global sourcing, trade, and other macroeconomic indicators. The end product, the Model for European Industry Circularity and Climate Change mitigation (MIC3), will allow to establish the required capacities and provide useful insights for industrial circularity performance and decarbonisation. MIC3, the ‘satellite’ modules comprising it and the scenario exercises stemming from it will be entirely co-developed and validated with relevant stakeholders from industry, policy, and civil society, as well as used to inform assessments and transition strategies, at EU and country level, at global level, and within 4 heterogeneous regional industry clusters in Europe, to ensure their usability and exploitation in real-world use cases.